Abstract #0366

Rapid High-Resolution Mapping of Brain Metabolites and Neurotransmitters Using Hybrid FID/SE-J-Resolved Spectroscopic Signals

Yibo Zhao^1,2, Yudu Li^1,2, Jiahui Xiong^1,2, Rong Guo^1,2, Yao Li^3,4, and Zhi-Pei Liang^1,2

¹Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ²Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ³School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, ⁴Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China

J-resolved MRSI is a powerful tool for separating overlapping resonances in conventional MRSI, which is especially useful for mapping neurotransmitters like γ-aminobutyric acid and glutamate. A major practical limitation of J-resolved MRSI lies in its long data acquisition time required to sample the high-dimensional data space using spin-echo-based sequences. In this work, we present a novel hybrid FID/SE data acquisition scheme to accelerate J-resolved MRSI. The proposed method has been validated using phantom and in vivo experimental data, producing high-quality 3D spatial maps of brain metabolites and neurotransmitters within clinically feasible time.

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