Diffusion-weighted MRS was successfully implemented on a 3T Connectom system reaching b-values of 25 ms/um2 at a short TE of 30 ms and a moderate TM of 65 ms. Motion-compensation based on the water peak was found feasible up to the highest b-value and can be supplemented by scaling to the macromolecule peak intensity at 0.9 ppm. Non-Gaussian diffusion behavior was detected for multiple metabolites and was modeled with biexponential and kurtosis representations. In addition, a macromolecular spectrum could be determined by diffusion weighting and simultaneous modeling, which can now be used for quantification in clinical short TE MRS.
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