Abstract #0347

Repeated Muscle Contraction increases Creatine Kinase Reaction Rate and Shortens Phosphocreatine Recovery in Mouse Skeletal Muscle

Kihwan Kim¹, Yuning Gu¹, Gahee Kim¹, Mei Wong¹, Bryan Clifford ^2,3, Sherry Huang¹, Zhi-Pei Liang^2,3, and Xin Yu^1,4

¹Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, ²Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ³Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁴Case Center for Imaging Research, Case Western Reserve University, Cleveland, OH, United States

This study examined the effects of muscle contraction, induced by electrical stimulation, on creatine kinase (CK) reaction rate and the rate of phosphocreatine (PCr) recovery after its transient depletion in mouse skeletal muscle using phosphorous-31 (³¹P) magnetic resonance fingerprinting and dynamic ³¹P magnetic resonance spectroscopy. Our results showed that electrical stimulation induced a significant increase in CK reaction rate by ~14%, as well as an increased in PCr recovery rate by 26%, suggesting a positive preconditioning effect induced by electrical stimulation.

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