Abstract #0341

T2 mapping in healthy and diseased muscle using optimized extended phase graph algorithms in four clinical cohorts

Kevin Keene^1,2, Jan-Willem Beenakker^1,3, Melissa Hooijmans⁴, Karin Naarding^2,5, Erik Niks², Louise Otto⁶, Ludo van der Pol⁶, Martijn Tannemaat², Hermien Kan^1,5, and Martijn Froeling⁷

¹Department of Radiology, C.J. Gorter center for high field MRI, Leiden University Medical Center, Leiden, Netherlands, ²Department of Neurology, Leiden University Medical Center, Leiden, Netherlands, ³Department of Ophthalmology, Leiden University Medical Center, Leiden, Netherlands, ⁴Amsterdam University Medical Center, Amsterdam, Netherlands, ⁵Duchenne Center Netherlands, Utrecht, Netherlands, ⁶Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, Netherlands, ⁷Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands

Multi-echo spin-echo transverse relaxometry mapping using multi-component models is used to study disease activity in neuromuscular disease. A recent model using extended phase graphs (EPG) was introduced to obtain separate T2 values for water and fat, accounting for B1 and stimulated echoes. We improved this model and showed the importance of including flip angle slice profiles with a chemical shift displacement in the slice direction and correct calibration methods for the T2 of the fat component. We showed its performance in four clinical cohorts, and showed a gradual decline in T2_water with increasing fat fractions.

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