Abstract #0288

Extracellular pH Changes Induced by Immuno-Thermal Ablation in a Murine Colorectal Cancer Model

Daniel Coman¹, Ryan J Slovak^2,3, Fahmeed Hyder^1,4,5, and Hyun S Kim^1,2,5,6

¹Radiology & Biomedical Imaging, Division of Bioimaging Sciences, Yale University School of Medicine, New Haven, CT, United States, ²Radiology & Biomedical Imaging, Section of Interventional Radiology, Yale University School of Medicine, New Haven, CT, United States, ³University of Connecticut School of Medicine, Farmington, CT, United States, ⁴Department of Biomedical Engineering, Yale University School of Medicine, New Haven, CT, United States, ⁵Yale Cancer Center, Yale University School of Medicine, New Haven, CT, United States, ⁶Department of Internal Medicine, Section of Medical Oncology, Yale University School of Medicine, New Haven, CT, United States

Acidification of tumor microenvironment is associated with aggressive tumor growth and facilitate resistance to anti-cancer therapies. Extracellular pH (pH_e) mapping with BIRDS is used to differentiate ablated and non-ablated tumors in the setting of systemic immunotherapy of murine colorectal cancer. Combination of Cryoablation with Dual Immune Checkpoint Blockade (DICB) resulted in a significant pH_e increase compared to control tumors. This work demonstrates the feasibility of measuring pH_e with BIRDS in a murine colorectal cancer model. pH_e imaging could serve as a non-invasive imaging biomarker for tumor microenvironment assessment and monitoring of metabolic changes after immuno-thermal ablation therapy.

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