We investigated presurgical resting-state fMRI (rsfMRI) in 9 patients with brain tumors using high-speed multiband-EPI (TR:400ms) with real-time data quality monitoring for seed-based localization of sensorimotor and language networks. The Euclidean distance between intra-operative electrocortical-stimulation (ECS) and rsfMRI connectivity and task-activation in motor cortex, Broca’s and Wernicke’s areas was 5-13mm, except for discordant rsfMRI localization of Wernicke’s area in one patient due to possible altered neurovascular coupling. A secondary objective was to accelerate encoding using echo-volumar-imaging. This study demonstrates the potential of high-speed rsfMRI for presurgical mapping and clinically-acceptable concordance with task-based fMRI and ECS localization.
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