Abstract #0240

White matter tracts organization in patients with polymicrogyria and lissencephaly

Filippo Arrigoni¹, Denis Peruzzo¹, Simone Mandelstam^2,3,4,5, Gabriele Amorosino¹, Daniela Redaelli¹, Romina Romaniello⁶, Richard Leventer^2,3,4, Renato Borgatti⁶, Marc Seal^2,4, and Joseph Yuan-Mou Yang^2,3,4

¹Neuroimaging Lab, Scientific Institute, IRCCS E. Medea, Bosisio Parini, Italy, ²Murdoch Children’s Research Institute, Parkville, Australia, ³Royal Children’s Hospital, Parkville, Australia, ⁴The University of Melbourne, Parkville, Australia, ⁵The Florey Institute of Neuroscience and Mental Health, Parkville, Australia, ⁶Scientific Institute, IRCCS E. Medea, Bosisio Parini, Italy

White matter (WM) tracts organization in 42 polymicrogyria (PMG) and 8 lissencephaly (LIS) patients were characterized using the tissue-specific Constrained Spherical Deconvolution modelling technique. Structural appearance of 9 major WM tracts were judged using fiber orientation distribution based direction-encoded color maps and probabilistic algorithm based tractography reconstructions. More abnormal-appearing WM tracts were identified in LIS compared to PMG. Degrees of superior longitudinal fasciculus and cingulum abnormalities were associated with PMG distribution and severity. Thickened superior fronto-occipital fasciculus was demonstrated in three patients. Patterns of WM tracts involvement were related to PMG and LIS distribution and subgroups.

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