Impaired brain glucose consumption is a possible trigger of Alzheimer’s disease (AD). Animal models can help characterize each contributor to the cascade independently. Here we report a comprehensive longitudinal study of functional connectivity, white matter microstructure and brain glucose metabolism using resting-state fMRI, diffusion MRI and FDG-PET in the intracerebroventricular-streptozotocin rat model of AD. Our study highlights the dynamics of how brain insulin resistance affects brain structure and function, and identifies potent MRI-derived biomarkers to track neurodegeneration in human AD and diabetic populations.
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