Tremor dominant PD and ET often pose a diagnostic difficulty in view of overlapping clinical features. We aimed at distinguishing the two using the novel technique of QSM to measure iron deposition in various gray matter nuclei including the substantia nigra pars compacta(SNPc). A statistically significant difference was seen in the QSM values of the SNPc, SNPr and caudate nucleus. ROC curve analysis showed a sensitivity and specificity of 90 and 87.5% respectively using a cut off value of 12 ppb for the SNPc. Thus, QSM is a potentially useful problem solving technique for distinguishing tremor dominant PD from ET.
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