In this study, we aimed to investigate the association of Apolipoprotein E (ApoE) gene polymorphism and caudate functional connectivity in mild cognitive impairment of Parkinson’s disease (PD-MCI), using resting-state functional magnetic resonance imaging (rs-fMRI) and genotyping. Our findings revealed that gene-brain-behavior associations involve alterations of caudate activity with posterior cortical, thereby provide potential imaging-based markers that contribute to the early diagnosis and monitoring of PD-MCI.
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