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Abstract #0191

Altered lactate dynamics with age in human brain during sleep

Manoj K. Sammi1, Katherine Powers1, Chloe Robinson1, Selda Yildiz1,2, Miranda Lim2,3,4,5,6, Jeffrey J Iliff7,8,9,10,11, and William D Rooney1,2,5,9
1Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, 2Department of Neurology, Oregon Health & Science University, Portland, OR, United States, 3VA Portland Health Care System, Portland, OR, United States, 4Department of Medicine, Division of Pulmonary and Critical Care Medicine, Oregon Health & Science University, Portland, OR, United States, 5Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, United States, 6Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR, United States, 7Department of Neurology, University of Washington, Seattle, WA, United States, 8Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, Portland, OR, United States, 9Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, United States, 10VISN 20 Mental Illness Research, Education and Clinical Center (MIRECC), VA Puget Sound Health Care System, Seattle, WA, United States, 11Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, United States

Lactate dynamics during sleep-awake cycle in human brain are studied non-invasively using single voxel diffusion weighted magnetic resonance spectroscopy (MRS) technique with simultaneous polysomnography (PSG) recordings to characterize sleep stages. Awake lactate apparent diffusion coefficients (ADC) values are large compared to other brain metabolites and may support active transport - Astrocyte-Neuron Lactate Shuttle (ANLS) mechanism. Lactate ADC are reduced in deep sleep stage in young subjects but are unchanged in older subjects. These results may reflect different interstitial fluid exchange activity or changed metabolic state with aging and require further research.

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