An implementation of a transverse isotropic model with fiber directions defined by DTI was added to our finite element model-based nonlinear inversion MRE platform. The algorithm can recover accurate images of complex valued shear modulus, shear anisotropy, and tensile anisotropy from a realistic brain simulation. In vivo application to multi-excitation brain MRE data produced promising results, maintaining high quality images for the base shear modulus and damping ratio, while recovering additional images of anisotropy which may be useful for characterizing diseases affecting white matter tracts or muscle.
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