Abstract #0147

Impact of Single Fraction Stereotactic Radiosurgery vs. Hypofractionated Radiation Therapy on CEST and MT Parameters of Brain Metastases

Hatef Mehrabian¹, Wilfred W Lam¹, Hany Soliman^1,2,3, Sten Myrehaug^2,3, Arjun Sahgal^1,2,3, and Greg J Stanisz^1,4

¹Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, ²Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ³Radiation Oncology, University of Toronto, Toronto, ON, Canada, ⁴Medical Biophysics, University of Toronto, Toronto, ON, Canada

Brain metastases are treated with single fraction stereotactic radiosurgery (sf-SRS) or hypofractionated radiation therapy (HFTR). CEST was previously shown to identify responders to sf-SRS within one-week post-treatment. This study investigated the differences in CEST and MT properties of brain metastases treated with sf-SRS and 5 fraction HFRT (5f-HFRT) one week after treatment. We observed statistically significantly larger reduction in CEST properties of tumours treated with sf-SRS compared to those treated with 5f-HFRT. However, changes in MT properties of the two cohort were similar. Such differences should be considered when evaluating response of brain metastases to radiotherapy using CEST and MT.

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