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Abstract #0130

Hyperpolarized 13C-glucose MRS: a potential biosensor to visualize the infiltrative front in GBM

Mor Mishkovsky1, Olga Gusyatiner2, Bernard Lanz1, Cristina Cudalbu3, Irene Vassallo2, Marie-France Hamou2, Jocelyne Bloch2, Arnaud Comment4, Rolf Gruetter1,3,5,6, and Monika Hegi2
1Laboratory for Functional and Metabolic Imaging (LIFMET), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 2Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, 3Centre d'Imagerie Biomédicale (CIBM), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 4General Electric Healthcare, Chalfont St Giles, United Kingdom, 5Department of Radiology, University of Geneva (UNIGE), Geneva, Switzerland, 6Department of Radiology, University of Lausanne (UNIL), Lausanne, Switzerland

Glioblastoma (GBM) is the most malignant primary brain tumor in adults. Aberrant glucose metabolism is considered a hallmark of cancer, via the so-called ‘Warburg Effect’, however recent studies show distinct metabolic profile associated with the invasive phenotype in GBM, indicating active glucose oxidation. Hyperpolarized (HP) endogenous compounds, provides real-time metabolic information which is related to enzymatic activity. The aim of the present study was to apply HP 13C-glucose MRS in patient-derived GBM models and to investigate glucose metabolism in the infiltrative front of GBM, which potentially would enable to differentiate the invasive front of GBM from normal brain.

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Abstract