Abstract #0102

Dynamic PRF and T1-based 3D Thermometry in the Liver using a Variable Flip Angle Stack-of-Radial Technique

Le Zhang¹, Tess Armstrong^1,2, and Holden H. Wu^1,2,3

¹Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, United States, ²Physics and Biology in Medicine, University of California, Los Angeles, Los Angeles, CA, United States, ³Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States

MR thermometry in the liver is challenged by mismatch between baseline and dynamic images caused by motion, leading to temperature errors. To address motion, previous methods had to compromise spatial coverage to increase temporal resolution. We propose a variable-flip-angle (VFA) 3D stack-of-radial technique for combined proton resonance frequency shift (PRF) and T₁-based MR thermometry with volumetric coverage and high spatiotemporal resolution. Accurate VFA T₁ calculation is achieved by synthesizing B₁+ maps that match the liver position in dynamic images. A multi-baseline approach is used for accurate dynamic PRF measurements. Results from non-heating scans demonstrate reliable liver T₁ and PRF measurements.

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