Abstract #0088

A first-in-child feasibility study of a new mini-capsule medical device to measure whole gut transit in pediatric constipation using MRI (MAGIC)

Hayfa Sharif^1,2, Nichola Abrehart¹, Caroline Hoad^1,3, Kathryn Murray^1,3, Alan Perkins^1,4, Penny Gowland³, Robin Spiller¹, Roy Harris¹, Sian Kirkham⁵, Sabarinathan Loganathan⁵, Michalis Papadopoulos⁵, the Young Persons Advisory Group (YPAG)⁶, David Devadason⁵, and Luca Marciani¹

¹Nottingham Digestive Diseases Centre and NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom, ²Clinical Radiology, Amiri Hospital, Ministry Of Health, Civil Service Commission, Kuwait, ³Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, ⁴Medical Physics and Clinical Engineering, Nottingham University Hospitals, Queen’s Medical Centre, Nottingham, United Kingdom, ⁵Nottingham Children’s Hospital, Nottingham University Hospitals NHS Trust, Queen’s Medical Centre, Nottingham, United Kingdom, ⁶NUH YPAG, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom

We developed a new MRI mini-capsule marker device to measure whole gut transit (WGTT) in pediatric constipation to overcome image quality and ionizing radiation limitations of current X-ray methods. Thirty five healthy children and 16 patients with constipation were asked to swallow a number of mini-capsules and imaged, following a common X-ray radiopaque marker protocol. The capsules were imaged successfully in the colon. WGTT was calculated from the capsules count and was significantly longer in the patients compared to the controls. The study also showed excellent feasibility and safety of using the new device and methods in children with constipation.

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