Abstract #0086

Free-Breathing Volumetric Liver R2* Quantification in Pediatric Patients Using 3D Self-Gating Motion-Compensated Stack-of-Radial MRI

Xiaodong Zhong¹, Houchun H Hu², Tess Armstrong^3,4, Marcel D Nickel⁵, Stephan A.R. Kannengiesser⁵, Vibhas Deshpande⁶, Berthold Kiefer⁵, and Holden H Wu^3,4

¹MR R&D Collaborations, Siemens Healthcare, Los Angeles, CA, United States, ²Department of Radiology, Nationwide Children's Hospital, Columbus, OH, United States, ³Department of Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States, ⁴Department of Physics and Biology in Medicine, University of California Los Angeles, Los Angeles, CA, United States, ⁵MR Application Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany, ⁶MR R&D Collaborations, Siemens Healthcare, Austin, TX, United States

Liver fat and iron quantification is of growing interest. However, it is challenging and sometimes impossible to perform breath-hold MRI acquisitions in children. Using a breath-hold 3D Cartesian method as reference, a self-gating free-breathing 3D stack-of-radial liver R₂^* quantification technique was evaluated. Results showed that the free-breathing stack-of-radial technique accurately quantified fat even without self-gating, while free-breathing R₂^* quantification had biases caused by respiratory motion and self-gating was necessary for accurate R₂^* quantification in pediatric subjects. This technique has potential for accurate and efficient free-breathing quantification of both liver fat and iron in pediatric patients.

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