Abstract #0065

Virtual hypoxia and structural network alterations in multiple sclerosis: a combined 23Na and diffusion MRI study

Adil Maarouf^1,2, Hanna Bou Ali¹, Pierre Besson¹, Jan Patrick Stellman^1,3, Soraya Gherib¹, Fanelly Pariollaud¹, Arnaud Le Troter¹, Maxime Guye^1,3, Patrick Viout¹, Jean Pelletier^1,2, Jean-Philippe Ranjeva¹, Bertrand Audoin^1,2, and Wafaa Zaaraoui¹

¹Aix-Marseille Université, CNRS, CRMBM, Marseille, France, ²APHM, Hôpital de la Timone, Pôle de Neurosciences Cliniques, Service de Neurologie, Marseille, France, ³APHM, Hôpital de la Timone, Pôle d’Imagerie Médicale, CEMEREM, Marseille, France

Virtual hypoxia is a key factor in the induction of pathological processes in multiple sclerosis. ²³Na-MRI is an emerging technique in virtual hypoxia exploration, with previous studies showing relevance of grey matter sodium accumulation in MS. In the present study, we showed that grey matter sodium accumulation is mainly driven by accumulation in the most connected cortical regions (called hubs) and correlate with disability. This study provides an insight in several processes of energy failure and brain reorganization in MS.

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