This study investigated the correlation between T2w-hyperintense lesions to the peripheral nervous system (PNS) and the central nervous system (CNS) in multiple sclerosis (MS) by combining 3 Tesla magnetic resonance neurography (MRN) and 3 Tesla CNS MRI. It was found that CNS lesions and PNS lesions were inversely correlated (r=-0.432; p=0.0002). This finding might help to elucidate the underlying pathomechanism of PNS involvement in MS by indicating that PNS demyelination in MS does not occur secondary to CNS lesions in the sense of Wallerian degeneration.
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