In this study, the generalization capacity of the artificial neural network for myelin water imaging (ANN-MWI) is explored by testing datasets with different (1) scan protocols (resolution, RF shape, and TE), (2) noise levels, and (3) types of disorders (NMO and edema). The ANN-MWI results show high reliability in generating myelin water fraction maps from the datasets with different resolution and noise levels. However, the increased errors are reported for the datasets with the different RF shape, TEs, and disorder type.
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