Abstract #0047

A study on Inhomogeneous Magnetization Transfer in Myelin and Intra-/Extra-cellular Water at 7T

Michelle H Lam^1,2, Valentin H Prevost², Andrew Yung², and Piotr Kozlowski^1,2,3,4

¹Physics, University of British Columbia, Vancouver, BC, Canada, ²UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada, ³Radiology, University of British Columbia, Vancouver, BC, Canada, ⁴International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, BC, Canada

Inhomogeneous magnetization transfer (ihMT) is a novel MR imaging technique that could be used for myelin-specific imaging if the sequence is properly tuned to filter components with short dipolar relaxation time (T_1D). It is believed that ihMT’s dependence on T_1D serves as a method to extract the myelin-related signal, due to its longest dipolar order among the brain structures. Here, we have combined two myelin imaging techniques, ihMT and myelin water imaging (MWI), to study myelin and intra-/extra-cellular water’s contribution to the overall ihMT signal.

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