Abstract #0039

A comparison of phase image and quantitative susceptibility mapping in identifying inflammation in chronic multiple sclerosis lesions

Xianfu Luo^1,2, Ulrike W. Kaunzner³, Thanh D. Nguyen¹, Yeona Kang⁴, Elizabeth Sweeney⁵, Weiyuan Huang¹, Yi Wang¹, and Susan Gauthier³

¹Department of Radiology, Weill Medical College of Cornell University, New York, NY, United States, ²Department of Radiology, Northern Jiangsu People's Hospital, Yangzhou, China, ³Department of Neurology, Weill Medical College of Cornell University, New York, NY, United States, ⁴Department of Radiology/Nuclear Medicine, Weill Medical College of Cornell University, New York, NY, United States, ⁵Department of Healthcare Policy and Research, Weill Medical College of Cornell University, New York, NY, United States

Both MR phase imaging and quantitative susceptibility mapping (QSM) are used to assess the presence of chronic active multiple sclerosis lesions. It is important to evaluate which measure can detect ongoing inflammation in chronic active lesions most accurately. This study combined PK11195-PET with QSM versus phase imaging, and demonstrated that QSM can detected higher uptake of PK11195, as compared to phase imaging.

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