Abstract #0034

High Resolution Water Exchange Rate Mapping using 3D Diffusion Prepared Arterial Spin Labeled Perfusion MRI

Qihao Zhang¹, Thanh D Nguyen², Jana Ivanidze³, and Yi Wang³

¹Cornell University, Ithaca, NY, NY, United States, ²Weill Cornell Medicine College, New York, NY, United States, ³Weill Cornell Medicine, New York, NY, United States

In this work, we propose an optimized acquisition for high resolution water exchange rate (k_w) mapping, that uses adiabatic RF pulses, 3D fast spin echo readout, regularized inversion to a direct model of the water exchange rate, and fast T1 mapping. Feasibility and superior performance is shown in a regional based analysis in 6 healthy subjects.

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