Towards patient specific dispersion correction for more accurate quantification in pCASL: modeling and experimental findings

This abstract compares quantified perfusion values of the standard model and a new dispersion model based on an AIF using the ASLIF-sequence. For different ATTs, the voxel´s signal was simulated using the dispersion model. The simulations show that the standard model overestimates the signal. This may result from lack of dispersion effects especially in the inflow phase of the labeled bolus. Consequently, the determined perfusion values vary for different ATTS. Thus, using an AIF based on an acquired patient specific reference bolus instead could improve the stability and robustness of quantified perfusion values.