Abstract #0014

Gd3+ Deposition as an Underestimated Hazard? – Potential Masking of Gadolinium Long-Term Deposition in Biological Regimes

Patrick Werner^1,2, Patrick Schuenke¹, Antje Ludwig³, Daria Dymnikova⁴, Christian Teutloff⁴, Matthias Taupitz⁵, and Leif Schröder¹

¹Leibniz-Forschungsinstitut fuer Molekulare Pharmakologie (FMP), Berlin, Germany, ²BIOphysical Quantitative Imaging Towards Clinical Diagnosis (BIOQIC), Berlin, Germany, ³Center for Cardiovascular Research (CCR), Charite Berlin, Berlin, Germany, ⁴Freie Universität Berlin, Berlin, Germany, ⁵Department of Radiology, Charite Berlin, Berlin, Germany

Gd³⁺-ions can be released from GBCAs after in vivo application and polysaccharides like glycosaminoglycans are candidates for binding of released Gd³⁺-ions by acting as competing chelators. We showed that the chelation of Gd³⁺-ions to polysaccharides cause an increase of R₁ due to the high relaxivity of such complexes. However, at high GAG/Gd³⁺ ratios and in cell experiments, we observed a decrease of R₁ after the chelation of Gd³⁺. Our results demonstrate the importance of more in vivo-like setups for the investigation of gadolinium transchelation processes to prevent an underestimation of the amount of deposited gadolinium in biological tissues.

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