Abstract #5039

Using D2O As a Diffusible Tracer in Characterizing Tumor Properties on Mice

Pei-Lun Yu¹, Ming Cheng¹, Xiayu Lyu¹, Sheng-Min Huang¹, Kung-Chu Ho², and Fu-Nien Wang¹

¹Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, ²Division of Nuclear Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan

As a diffusible tracer, D₂O was employed as a negative contrast agent in investigating tumor perfusion in this study. Results show that the transfer constant derived from D₂O perfusion is able to characterize tumor flow properties. Furthermore, we also demonstrated that the initial area under curve of D₂O perfusion has potential in detecting the flow difference between tumor and normal tissue, suggesting the feasibility of semi-quantitative indices for D₂O perfusion.

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