Dynamic contrast-enhanced MR imaging (DCE-MRI) is an effective tool to quantify inflammation in carotid atherosclerotic plaque, while little is known on the effect of the injection protocol on carotid DCE-MRI. In this study, the effect of the contrast injection protocol, including injection dose and effective injection rate (decided by the injection rate and concentration) on the pharmacokinetic parameters estimation in carotid DCE-MRI were investigated. The results indicated that high injection dose (~0.1mmol/kg) with relative low effective injection rate (~0.5 mmol/s, effective injection rate = rate (ml/s) × concentration (mol/L)) was recommended for the simulated bright-blood DCE protocol.
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