Caffeine is a commonly used neurostimulator that also produces cerebral vasoconstriction by antagonizing adenosine receptors. Previous studies demonstrate that acute caffeine intake leads to significant cerebral blood flow (CBF) reduction but have not investigated the effect on blood-brain barrier (BBB) water permeability. Here we provide an initial investigation into the effect of caffeine on BBB water permeability parameters, water extraction fraction (Ew) and permeability surface area product (PSw), using the recently developed Intrinsic Diffusivity Encoding of Arterial Labeled Spins (IDEALS). Significant reductions in CBF, Ew, and PSw were observed after administration of 200 mg caffeine.
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