Abstract #5009

Acquisition protocol for glucoCESL MRI in the human brain at 7T with reduced motion-induced artifacts

Philip S. Boyd¹, Johannes Breitling¹, Ferdinand Zimmermann¹, Andreas Korzowski¹, Moritz Zaiss², Kai Herz², Patrick Schuenke¹, Nina Weinfurtner³, Heinz-Peter Schlemmer³, Mark E. Ladd¹, Peter Bachert¹, Daniel Paech³, and Steffen Goerke¹

¹Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ²High‐field Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany, Tübingen, Germany, ³Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

In this study, an acquisition protocol for glucoCESL MRI examinations in the human brain is presented, that was optimized for suppression of motion-induced artifacts. This was achieved by using a combination of (i) a 3D imaging readout, which enabled co-registration of the acquired images over the course of time, and (ii) a ΔR_1ρ contrast based on quantitative R_1ρ maps instead of R_1ρ-weighted images. The presented acquisition protocol improves the applicability of glucose-weighted MRI for examinations in humans where motion is present. Feasibility was verified by examination in a first patient with glioblastoma.

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