Abstract #5001

Quantification of brain perfusion using dynamic glucose-enhanced MRI

Charlotte Debus^1,2, Patrick Schuenke^3,4, Ralf Floca^2,5, Myriam Keymling⁶, Amir Abdollahi^1,2, Alexander Radbruch⁶, Peter Bachert^4,7, Mark E Ladd^4,7,8, Heinz-Peter Schlemmer⁶, and Daniel Paech⁶

¹Translational Radiation Oncology, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Heidelberg, Germany, ²Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany, ³Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany, ⁴Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ⁵Division of Medical Image Computing, German Cancer Research Center (DKFZ), Heidelberg, Germany, ⁶Division of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ⁷Faculty of Physics and Astronomy, University of Heidelberg, Heidelberg, Germany, ⁸Faculty of Medicine, University of Heidelberg, Heidelberg, Germany

Dynamic glucose-enhanced (DGE) MRI was analyzed to derive quantitative parameters related to tissue perfusion, microvasculature and glucose uptake in the human brain. Adiabatically prepared T1ρ-weighted DGE-MRI was performed on seven healthy volunteers and one glioblastoma patient with a 7T scanner after administration of D-glucose. DGEρ time curves were investigated in different morphological structures of the healthy brain and in tumor tissue by extraction of semi-quantitative parameters and pharmacokinetic modelling using the extended Tofts model. Results show that application of semi-quantitative and pharmacokinetic modeling approaches for quantification of DGE-MRI is feasible in both healthy humans and brain tumor patients.

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