Abstract #4989

Analysis of magnetization transfer (MT) influence on quantitative mapping of T2 relaxation time

Dvir Radunsky¹, Tamar Blumenfeld-Katzir¹, Osnat Volovyk², Tal Assaf², Daniel Barazany³, Galia Tsarfaty⁴, and Noam Ben-Eliezer^1,5,6

¹Department of Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel, ²Department of Chemical Physics, The Weizmann Institute, Rehovot, Israel, ³Strauss computational neuroimaging center, Faculty of Life sciences, Tel Aviv University, Tel Aviv, Israel, ⁴Department of Diagnostic Imaging, Sheba Medical Center, Ramat Gan, Israel, ⁵Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel, ⁶Center for Advanced Imaging Innovation and Research (CAI2R), New-York University Langone Medical Center, New York, NY, United States

Quantification of T₂ values is valuable for a broad range of pathologies, yet, highly challenging due to the contamination of rapid multi-echo spin-echo (MESE) protocols by stimulated and indirect echoes. Bloch-simulations based methods, such as the echo modulation curve (EMC) algorithm, take these signal fluctuations into account and produce accurate, precise, and reproducible T₂ values. This work provides detailed analysis of magnetization transfer (MT) effect on MESE signal and on the ensuing T₂ values, investigating different protocol settings, and using three models: in vitro urea phantom, ex vivo horse brain and in vivo human brain.

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