In this study, novel Manganese-based contrast agents (MnCAs) were evaluated by relaxometry techniques (NMR and phantom imaging) and tested in naïve pigs using a contrast-enhanced MRA protocol and compared to the well-established agent GdDOTA. Despite some differences in T1 and T2 relaxation performance, both MnCAs and GdDOTA provided strong vascular T1-enhancement in naïve pig imaging thus providing initial evidence that MnCAs could be utilized for a clinical application.
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