Abstract #4900

Sensitivity of in vivo myelin imaging techniques to detect subtle changes in myelin lipid and protein content in post-mortem multiple sclerosis brain tissues

Vanessa Wiggermann^1,2,3, Verena Endmayr⁴, Enedino Hernandez-Torres^2,3, Romana Höftberger⁵, Gregor Kasprian⁶, Alexander Rauscher^1,2,3,7, and Simon Hametner⁸

¹Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, ²Pediatrics, University of British Columbia, Vancouver, BC, Canada, ³UBC MRI Research Centre, Univeristy of British Columbia, Vancouver, BC, Canada, ⁴Neuroimmunology, Medical University of Vienna, Vienna, Austria, ⁵Institute of Neurology, Medical University of Vienna, Vienna, Austria, ⁶Biomedical Imaging and Image‐Guided Therapy, Medical University of Vienna, Vienna, Austria, ⁷Radiology, Univeristy of British Columbia, Vancouver, BC, Canada, ⁸Neuropathology, Medical University of Göttingen, Göttingen, Germany

Previous post-mortem single-slice myelin water fraction (MWF) measurements have shown good correlations with the myelin lipid fraction across tissue types. However, the role of protein content was not assessed nor have validations been performed for the whole brain 3D-Gradient and Spin Echo (GraSE) technique that has been employed in recent studies. We showed that 3D-GraSE based MWF measurements reliably distinguished regions of different myelin integrity reflective of difference in myelin lipid and protein content. In contrast, subtle variations in MWF within tissue classes or between persons may relate to differences in protein content.

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