The super-resolution-based, isotropic 4D-MRI, and orthogonal cine imaging pulse sequence (SR-4D-SOPI) was developed and evaluated in this work. Cine imaging was acquired at more than 3 frames per second in sagittal and coronal planes simultaneously while also acquiring two orthogonal 4D-MRI volumes. The volumes were combined using super-resolution methods to create an isotropic 4D-MRI to be used for dose reconstruction following each fraction of abdominal or thoracic MR-guided radiation therapy.
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