Abstract #4536

Optimised T2 Preparation for Brain Imaging: Application to Compressed Sensing 3D T2 Mapping

Emilie Mussard^1,2,3, Tom Hilbert^1,2,3, Christoph Forman⁴, Ruud B. van Heeswijk^2,5, Reto Meuli², Jean-Philippe Thiran³, and Tobias Kober^1,2,3

¹Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, ²Department of Radiology, University Hospital (CHUV), Lausanne, Switzerland, ³LTS5, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ⁴Magnetic Resonance, Siemens Healthcare GmbH, Erlangen, Germany, ⁵Center for BioMedical Imaging (CIBM), Lausanne and Geneva, Switzerland

T2-mapping is becoming an important tool to detect pathological tissue; however, achieving high isotropic resolution is challenging. This work optimises a T2-prepared 3D compressed-sensing acquisition. Two T2-preparation modules (modified-BIR4, hyperbolic secant) and three Cartesian sampling trajectories (spiral, radial, VC-spiral) are explored. The NIST-ISMRM phantom and three in vivo subjects were scanned to test T2 accuracy and homogeneity. Results show more homogeneous and accurate T2 values with BIR4, due to a decreased sensitivity to B1. In vivo data showed more homogeneous T2 in WM using a radial trajectory. Based on these results, we propose an optimised 3D T2-mapping protocol of 9:48min.

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