Abstract #4463

MR imaging of a 3D-printed bioreactor with a dedicated radiofrequency coil for cellular level validation of quantitative MR metrics

Megan E Poorman^1,2, Slavka Carnicka¹, Jeanne E Barthold³, Michele N Martin¹, Karl F Stupic¹, Corey P Neu³, and Kathryn E Keenan¹

¹National Institute of Standards and Technology, Boulder, CO, United States, ²Department of Physics, University of Colorado Boulder, Boulder, CO, United States, ³Department of Mechanical Engineering, University of Colorado Boulder, Boulder, CO, United States

Quantitative MRI methods have the potential to push the clinical standard of care towards quantitative diagnosis. However, controlled systems are needed to study the effects of underlying cellular properties on the MRI signal to validate quantitative MRI measures. To meet this need, our group previously developed an MR-compatible bioreactor to monitor cell behavior using MRI validated with optical microscopy. The present work develops a dedicated RF coil for improved MR imaging of the bioreactor and uses it to explore the effects of cell culture on T1 and T2 in our system.

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