Abstract #4420

T1 Mapping at 7T Using a Novel Inversion-Recovery Look-Locker 3D-EPI Sequence

Rüdiger Stirnberg¹, Yiming Dong¹, Jonas Bause^2,3, Philipp Ehses¹, and Tony Stöcker^1,4

¹German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, ²High-Field MR Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany, ³Department for Biomedical Magnetic Resonance, University of Tuebingen, Tübingen, Germany, ⁴Department of Physics and Astronomy, University of Bonn, Bonn, Germany

We propose a novel Inversion-Recovery Look-Locker 3D-EPI sequence for rapid T₁ mapping. The inherent SNR benefit of a 3D acquisition, segmentation along both phase encode directions and a turbofactor introduced to reduce the number of required inversions can be traded freely for acquisition speed, SNR, resolution and geometric distortions. Aside from quantitative validation, two high-resolution T₁ mapping applications are demonstrated at 7T: whole-brain with minimal distortions, and reduced field-of-view with geometric distortions matched to corresponding fMRI data. The results show high T₁ accuracy for several turbofactor and flip angle combinations compared to a single-slice inversion-recovery 2D-EPI reference.

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