Quantitative perfusion imaging is challenging in the breast because the requisite arterial input function (AIF) is difficult to measure given the lack of large-caliber feeding arteries. To overcome this problem, we show that quantitative transport mapping (QTM), a new AIF-free perfusion model, is not only technically feasible in the breast, but has the potential to better distinguish malignant from benign breast lesions compared to conventional perfusion modeling.
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