Abstract #4386

Confounding Factors in Breast Magnetic Resonance Fingerprinting: B1+, Slice Profile and Diffusion Effects

Teresa Nolte^1,2, Mariya Doneva³, Thomas Amthor³, Peter Koken³, Nicolas Gross-Weege², Tianyu Han², Hannah Scholten², and Volkmar Schulz²

¹Philips Research Europe, Eindhoven, Netherlands, ²Physics of Molecular Imaging Systems, RWTH Aachen University, Aachen, Germany, ³Philips Research Europe, Hamburg, Germany

In this study, we evaluate the effect of three potentially confounding factors (B₁⁺ inhomogeneity, slice profile, diffusion) on the outcome of 2D Magnetic Resonance Fingerprinting measurements in the female breast for six healthy volunteers. Each of these factors was included into an MRF dictionary and matching results were compared to a reference dictionary that excluded the correction. For the given MRF sequence, both B₁⁺ inhomogeneity and slice profile correction affected the quantitative relaxation times in the female breast, whereas this was not the case for diffusion.

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