Abstract #4379

Free-Breathing Liver T1 and Fat Mapping Using a Golden-Angle-Ordered Variable Flip Angle Stack-of-Radial Sequence

Le Zhang¹, Tess Armstrong^1,2, and Holden H. Wu^1,2,3

¹Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, United States, ²Physics and Biology in Medicine Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA, United States, ³Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States

Measurement of T₁ and proton-density fat fraction (PDFF) in the liver can provide information about fibrosis and steatosis, respectively. Existing Cartesian acquisition schemes generally require breath-holding, which limits spatial coverage and may be difficult for sick, elderly or pediatric patients. In this study, we propose a golden-angle-ordered (GA) 3D stack-of-radial variable-flip-angle (VFA) sequence that can map T₁ and PDFF simultaneously with close to full liver coverage under five minutes during free-breathing. Pilot studies in phantom and healthy subjects demonstrate feasibility and show good measurement repeatability.

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