Mapping T1, T2, and proton density fat fraction of the liver using MR Fingerprinting with three-point DIXON and 6-peak fat model

An MR Fingerprinting (MRF) simultaneously combining the three-point DIXON (3P-DIXON) method for the fatty liver was proposed. The MRF-FISP sequence with multi-TR/TE/flip angle was developed. The six-peak fat model was used to calculate a dictionary for the MRF. Template matching using the acquired signal evolutions and the rough fat fraction map estimated by 3P-DIXON provided quantification of T1, T2, and fat fraction. The phantom and volunteer studies demonstrated the feasibility of our study.