Abstract #4359

Simultaneous PET/MRI to detect brain tumour metabolic and functional heterogeneity

Erica Silvestri^1,2, Marco Castellaro^1,2, Alessandro Palombit ^1,2, Silvia Facchini^2,3, Elena Monai^2,3, Domenico D'Avella^2,3, Alessandro Della Puppa³, Diego Cecchin^2,4, Maurizio Corbetta^2,3, and Alessandra Bertoldo^1,2

¹Department of Information Engineering, University of Padova, Padova, Italy, ²Padova Neuroscience Center, University of Padova, Padova, Italy, ³Department of Neuroscience, University of Padova, Padova, Italy, ⁴Department of Molecular Imaging, University of Padova, Padova, Italy

Demarcation for brain tumour neurosurgical resection is typically performed using Fluid Attenuated Inversion Recovery images hyperintensities. In this study, we investigated in glioma patients whether these hyperintensities represent structural alterations that are metabolically and functionally homogeneous using simultaneous measurements of quantitative 18-Fluoro-deoxyglucose PET and resting state functional magnetic resonance imaging. FLAIR hyperintense regions resulted to be heterogeneous both at metabolic and functional standpoint and only partially significantly altered when compared with contralateral homologous white matter. These results support the hypothesis that multi-parametric approaches might improve the outcome of brain surgery informing the resection procedure.

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