Abstract #4356

Qualitative and quantitative morphology/metabolism analysis of infantile spasms using PET/MR and efficacy evaluation of ACTH therapy

Haodan Dang¹, Jiajin Liu¹, Honghong Liu¹, Liping Zou², Xiang Feng³, Mu Lin⁴, Jiahe Tian¹, and Baixuan Xu¹

¹Nuclear medicine, the general hospital of people liberation army, PLA hospital, Beijing, China, ²Pediatrics, the general hospital of people liberation army, PLA hospital, Beijing, China, ³MR Scientific Marketing，Diagnostic Imaging，Siemens Healthcare. Beijing, P.R. China, Beijing, China, ⁴MR Collaboration，Diagnostic Imaging，Siemens Healthcare. Shanghai, P.R. China, Shanghai, China

This study aimed to investigate the diagnostic performance of positron emission tomography/magnetic resonance imaging (PET/MR) for structural/metabolic abnormality in infantile spasms. We evaluated both the morphology and parameters of PET/MR images by qualitative and quantitative assessment. Our results showed quantitative analysis of PET/MR images could improve the diagnosis of etiologic abnormality. Furthermore, the classification of etiology using PET/MR can indicate the efficacy of adrenocorticotropic hormone (ACTH) treatment and provide valuable information for surgery plan.

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