Abstract #4354

Calibrated fMRI as a Complementary Diagnostic Method for Epilepsy

Qikai Qin^1,2, Miao Zhang³, Peng Huang⁴, Wei Liu⁴, Hongping Meng³, Biao Li³, Bomin Sun⁴, Mu Lin⁵, Zheng Wang⁶, Raymond C. Stevens^1,2, and Garth J. Thompson¹

¹iHuman Institute, ShanghaiTech University, Shanghai, China, ²School of Life Science and Technology, ShanghaiTech University, Shanghai, China, ³Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ⁴Department of Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ⁵MR Collaboration, Siemens Healthcare Ltd., Shanghai, China, ⁶Institute of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China

Epilepsy, one of the most common neurological disorders, is a chronic and recurrent disorder of the brain characterized by unprovoked seizures. Unfortunately, conventional diagnostic methods are limited due to the difficulties of precise localization of the epileptogentic zone. Here, we introduce the calibrated functional MRI (fMRI) to calculate the oxygen to glucose index (OGI) with a combined PET/MR system. With this approach we were able to observe large decreases in relative OGI within the affected hemisphere of epileptic patients. Our method, if proven to locate epileptic foci better than glucose-PET methods alone, will represent an important new diagnostic tool for epilepsy.

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