Mesenchymal Stem Cells (MSCs) have potentials to be used for the treatment of bone diseases. We developed a new MRI method for detection of Fe-labeled MSCs. This protocol utilizes a resonance frequency shift induced by iron-oxide particles and allows imaging of grafted MSCs with a saturated signal from the host tissue. We compared retention of control and MSCs tagged with a high affinity to the bone tissue peptide. As compared with control, more tagged MSCs were detected at the injection area nine days after implantation. The new protocol allows
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