Abstract #4341

Ultrasmall iron oxide particle-enhanced MR imaging of fibrogenesis and fibrolysis of liver fibrosis in mice

Joao Piraquive¹, Sabrina Doblas¹, Bich-Thuy Doan², Philippe Garteiser¹, and Bernard E. Van Beers¹

¹Laboratory of Imaging Biomarkers, UMR 1149 INSERM-University Paris Diderot, Sorbonne Paris cité, Department of Radiology, Beaujon University Hospital Paris Nord, Clichy, France, ²Unité de technologies Chimiques et biologiques pour la santé (UTCBS), ENSCP Chimie-Paristech, UMR 8258, U1022, University Paris Descartes, Paris, France

The aim of our study was to assess if hepatic fibrogenesis and fibrolysis could by differentiated with USPIO-enhanced MR imaging in mice, based on differential uptake of fluorescent USPIO by macrophages. The change in R2* were significantly higher in the fibrogenesis group compared to the healthy group and the regression group 24 hours after the injection of USPIO. Higher USPIO uptake was observed with fluorescence microscopy during fibrogenesis relative to uptake in fibrolysis and healthy livers. Significant correlation was found between R2* and fluorescence intensity. These results suggest that the dynamics of fibrogenesis can be assessed with USPIO enhanced MR imaging.

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