For the imaging of hyperpolarized [2-13C]pyruvate, we propose a hybrid approach in which the closely spaced metabolic peaks of pyruvate, glutamate, citrate, acetoacetate, and acetyl-carnitine are measured using spectroscopic imaging, while the highly shifted [2-13C]Lactate peak is measured using selective excitation with a conventional fast imaging readout. We further demonstrate that a quadrature image reconstruction algorithm combining data from two fast imaging acquisitions, with the readout shifted by 1/2J, eliminates severe artifacts that normally arise when imaging a J-coupled system for which 1/J is comparable to the readout window.
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