Spectral-spatial pulses demand accurate frequency setting, which is difficult for studies using hyperpolarized 13C substrates, as the calibration has to be performed prior to the injection of the labelled molecule. In this study we retrospectively analysed human 13C brain studies, comparing three methods of scan calibration: study date, external reference phantom, and 1H frequency. The latter method outperformed the other 2 by a large margin: the SD of differences (predicted minus actual frequency of pyruvate) was 11 Hz with 1H frequency, 39 Hz using study date, and 40 Hz when referenced to an external phantom.
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