Abstract #4283

Phenylglyoxylic acid as a generic UV-induced radical precursor to hyperpolarize 13C-labelled substrates for in vivo metabolic studies

Irene Marco-Rius¹, Tian Cheng², Adam P Gaunt², Saket Patel³, Felix Kreis², Andrea Capozzi⁴, Alan J Wright², Kevin M Brindle², Olivier Ouari³, and Arnaud Comment^2,5

¹Institute for Bioengineering of Catalonia, Barcelona, Spain, ²University of Cambridge, Cambridge, United Kingdom, ³Aix-Marseille University, CNRS, ICR, Marseille, France, ⁴Department of Electrical Engineering, Center for Hyperpolarization in Magnetic Resonance, Technical University of Denmark, Lyngby, Denmark, ⁵GE Healthcare, Cambridge, United Kingdom

Photo-irradiation of phenylglyoxylic acid (PhGA) using visible light produces a non-persistent radical that, in principle, can be used to hyperpolarize any molecule. We show that PhGA can be used as a radical precursor to polarize photo-sensitive metabolic substrates (such as the gluconeogenic probe ¹³C-dihydroxyacetone) as well as ¹³C-glucose. We also present our preliminary DNP data obtained in PhGA-doped samples using a novel custom-built cryogen-free 7T/1.4K polarizer.

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