Abstract #4279

An Optimized GRASE Sequence for Preclinical and Human Hyperpolarized 13C Imaging

Shuyu Tang^1,2, Jeremy Gordon¹, Peng Cao¹, Robert Bok¹, Daniel Vigneron¹, and Peder Larson¹

¹University of California at San Francisco, San Francisco, CA, United States, ²University of California at Berkeley, Berkeley, CA, United States

An optimized GRASE sequence was developed for dynamic hyperpolarized ¹³C Imaging and demonstrated the feasibility for human brain research. The multi-echo signal can either be used to encode a 3D volume or as a 2D multi-echo approach to increase SNR or estimate T2. Varied crusher gradients were investigated to reduce the loss of longitudinal hyperpolarized ¹³C magnetization.

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